Details

Autor(en) / Beteiligte

• Kanjilal, Sanjit
• Shanker, Kaki Shiva
• Rao, Kotte Sagar
• Reddy, Kunduru Konda
• Rao, Bhamidipati V.S.K
• Kumar, Kota B. Shiva
• Kantam, Mannepalli L
• Prasad, Rachapudi B.N

Titel

Chemo-enzymatic synthesis of lipophilic ferulates and their evaluation for antioxidant and antimicrobial activities

Ist Teil von

• European journal of lipid science and technology, 2008-12, Vol.110 (12), p.1175-1182

Ort / Verlag

Weinheim: Wiley-VCH Verlag

Erscheinungsjahr

2008

Quelle

Wiley Online Library

Beschreibungen/Notizen

• An efficient chemo-enzymatic synthesis of ferulic acid-based structured lipids mimicking triacylglycerol with a pendant phenolic moiety was carried out for the first time. Initially, ferulic acid was reduced to coniferyl alcohol, followed by its esterification with fatty acids. The key step in the synthesis was dihydroxylation of the olefinic side chain of coniferyl ester, which was eventually esterified with fatty acids to generate phenolic structured lipids. Two such compounds of varying fatty acid chain lengths were synthesized in good yield. Structural confirmation of both compounds is based on IR, ¹H and ¹³C NMR, and MS techniques. The synthesized compounds were tested for in vitro antioxidant and antimicrobial activities. Both compounds exhibited moderate to good antioxidant activity. The phenolic structured lipid with only shorter-chain fatty acids showed antibacterial activity. Both compounds did not show any antifungal activity.