Details

Autor(en) / Beteiligte

• Barreiro, Elena
• Casas, José S.
• Couce, María D.
• Laguna, Antonio
• López-de-Luzuriaga, José M.
• Monge, Miguel
• Sánchez, Agustin
• Sordo, José
• Varela, José M.
• López, Ezequiel M. Vázquez

Titel

A Dinuclear Gold(I)-Silver(I) Derivative of 2-Cyclopentylidene-2-sulfanylacetic Acid and Related Complexes: Synthesis, Crystal Structures, Properties and Antitumor Activity

Ist Teil von

• European Journal of Inorganic Chemistry, 2011-03, Vol.2011 (8), p.1322-1332

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The dinuclear complex [AgAu(PPh3)2cpa] (H2cpa = 2‐cyclopentylidene‐2‐sulfanylacetic acid) was prepared by treating the precursor [Au(PPh3)(Hcpa)] with Ag(PPh3)NO3. The complex was characterised by spectroscopic methods (IR; 1H, 13C, 31P NMR) and mass spectrometry, and the structure was solved by a single‐crystal X‐ray diffraction study. Luminescence and theoretical studies were carried out, and the antitumor activity was studied in vitro against HeLa‐229, A2780 and A2780cis cell lines. The related gold(I)–gold(I), [(AuPPh3)2cpa], and silver(I)–silver(I), [(AgPPh3)2cpa], compounds were also prepared and studied in the solid state and in solution. A dinuclear gold(I)–silver(I) compound was prepared and characterised, and its luminescence and cytotoxicity were studied. A comparative study with related gold(I)–gold(I) and silver(I)–silver(I) compounds was carried out in the solid state and in solution.