Details

Autor(en) / Beteiligte

• Notni, Johannes
• Görls, Helmar
• Anders, Ernst

Titel

Zinc Thiolate Complexes [ZnLn(SR)]+ with Azamacrocyclic Ligands: Synthesis and Structural Properties

Ist Teil von

• European Journal of Inorganic Chemistry, 2006, Vol.2006 (7), p.1444-1455

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• A series of 24 novel zinc thiolate complexes containing saturated macrocyclic polyamine ligands with the general formula [Zn(Ln)(SR)]ClO4 (Ln: n‐dentate azamacrocyclic ligand) has been synthesized. Two different thiolate ligands (R = phenyl, benzyl) and 12 macrocyclic ligands with ring sizes varying from 11 to 16 atoms and containing three, four, and five nitrogen donors (including a new macrocyclic triamine ligand, 8‐methyl‐[11]aneN3) have been used. The solid‐state structures of 20 of the 24 complexes have been characterized by X‐ray diffraction. The crystal lattice of all compounds is comprised exclusively of monomers. The tetracoordinate N3S compounds exhibit Zn–S bond lengths ranging from 2.2259(5) to 2.2492(9) Å and the pentacoordinate N4S systems from 2.266(2) to 2.3200(7) Å. In addition, two complexes with the very rare N5S coordination environment for zinc have been found. They exhibit Zn–S bond lengths of 2.3782(7) and 2.42 Å (mean value of two independent molecules). The thiolate complexes are suitable model systems for the precursor proteins of matrix metalloproteases (pro‐MMPs) as well as for thiolate alkylating enzymes such as cobalamine‐dependent/independent methionine synthases, farnesyl transferase, and the Ada repair protein. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)