European journal of immunology, 1986-02, Vol.16 (2), p.209-212
1986
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Details
- Autor(en) / Beteiligte
- Titel
- Recombinant interleukin 2 enhances spontaneous insulin‐dependent diabetes in BB rats
- Ist Teil von
- European journal of immunology, 1986-02, Vol.16 (2), p.209-212
- Ort / Verlag
- Weinheim: WILEY‐VCH Verlag GmbH
- Erscheinungsjahr
- 1986
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Treatment of BB rats with recombinant interleukin 2 (IL 2) enhanced the development of spontaneous diabetes in these animals. A dose of 20 μg IL 2/kg body weight was administered twice daily for 80 days starting at 42 days of age. The rate of diabetes was doubled after IL2 administration (53% vs. 23%) and the onset of diabetes was found to be accelerated by a mean of 18 days. Histological analysis showed enhanced inflammation of islets and in addition interstitial pancreatis. It is concluded that IL2 has a regulatory effect on spontaneous organ‐specific autoimmunity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2980eISSN: 1521-4141DOI: 10.1002/eji.1830160218Titel-ID: cdi_crossref_primary_10_1002_eji_1830160218
- Format
- –
- Schlagworte
- Analysis of the immune response. Humoral and cellular immunity, Animals, Autoantibodies - immunology, Biological and medical sciences, Diabetes Mellitus, Type 1 - etiology, Diabetes Mellitus, Type 1 - pathology, Dose-Response Relationship, Drug, Female, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Immunobiology, Interleukin-2, Islets of Langerhans - drug effects, Lymphocyte Activation, Lymphocytes - immunology, Lymphokines, interleukins ( function, expression), Male, Pancreas - pathology, Rats, Rats, Inbred BB, Recombinant Proteins - toxicity, Regulatory factors and their cellular receptors