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Cis‐regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans
Developmental dynamics, 2009-12, Vol.238 (12), p.3080-3092
Nokes, Eva B.
Van Der Linden, Alexander M.
Winslow, Caron
Mukhopadhyay, Saikat
Ma, Kristin
Sengupta, Piali
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Nokes, Eva B.
Van Der Linden, Alexander M.
Winslow, Caron
Mukhopadhyay, Saikat
Ma, Kristin
Sengupta, Piali
Titel
Cis‐regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans
Ist Teil von
Developmental dynamics, 2009-12, Vol.238 (12), p.3080-3092
Ort / Verlag
New York: Wiley‐Liss, Inc
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
The generation of cellular diversity is dependent on the precise spatiotemporal regulation of gene expression by both cis‐ and trans‐acting mechanisms. The developmental principles regulating expression of specific gene subsets in individual cell types are not fully understood. Here we define the cis‐regulatory mechanisms driving expression of cell‐selective and broadly expressed genes in vivo in the AWB olfactory neuron subtype in C. elegans. We identify an element that is necessary to drive expression of neuron‐selective chemoreceptor genes in the AWB neurons, and show that this element functions in a context‐dependent manner. We find that the expression of broadly expressed sensory neuronal genes in the AWB neurons is regulated by diverse cis‐ and trans‐regulatory mechanisms that act partly in parallel to the pathways governing expression of AWB‐selective genes. We further demonstrate that cis‐acting mechanisms driving gene expression in the AWB neurons appear to have diverged in related nematode species. Our results provide insights into the cis‐regulatory logic driving cell‐specific gene expression, and suggest that variations in this logic contribute to the generation of functional diversity. Developmental Dynamics 238:3080–3092, 2009. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1058-8388
eISSN: 1097-0177
DOI: 10.1002/dvdy.22147
Titel-ID: cdi_crossref_primary_10_1002_dvdy_22147
Format
–
Schlagworte
Animals
,
Animals, Genetically Modified
,
Base Composition
,
Base Sequence
,
Caenorhabditis elegans
,
Caenorhabditis elegans - embryology
,
Caenorhabditis elegans - genetics
,
chemoreceptors
,
cis‐regulatory motifs
,
Conserved Sequence
,
Embryo, Nonmammalian
,
Gene Deletion
,
Gene Expression Regulation, Developmental
,
Models, Biological
,
Molecular Sequence Data
,
Olfactory Nerve - embryology
,
Olfactory Nerve - metabolism
,
olfactory neuron
,
Olfactory Receptor Neurons - embryology
,
Olfactory Receptor Neurons - metabolism
,
Regulatory Sequences, Nucleic Acid - physiology
,
Sequence Homology, Nucleic Acid
,
Species Specificity
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