ChemInform, 2010-11, Vol.41 (45), p.no-no
2010
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Details
- Autor(en) / Beteiligte
- Titel
- ChemInform Abstract: Versatile Synthesis of New Cytotoxic Agents Structurally Related to Hemiasterlins
- Ist Teil von
- ChemInform, 2010-11, Vol.41 (45), p.no-no
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2010
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- A series of structural analogues of the antimitotic tripeptides hemiasterlins is synthesized by a flexible approach using α‐bromoacid, e.g. (I), as starting material and an Ag2O‐promoted nucleophilic substitution as the key step Variation of (I), which is available from any diazotizable α‐amino acid and of the nucleophiles allows the generation of hemiasterlin libraries.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0931-7597eISSN: 1522-2667DOI: 10.1002/chin.201045189Titel-ID: cdi_crossref_primary_10_1002_chin_201045189
- Format
- –
- Schlagworte
- amination, amination, N‐alkylation, N‐arylation, amino acids, amino acids, peptides, anticancer activity, anticarcinogenic activity, anticarcinogenic activity, anticancer activity, diastereoselective syntheses, diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism), enantioselective syntheses (incl. cis/trans-isomerism), N-alkylation, N-arylation, peptides