Details

Autor(en) / Beteiligte

• Lam, Pui‐Ying
• Kutchukian, Peter
• Anand, Rajan
• Imbriglio, Jason
• Andrews, Christine
• Padilla, Hugo
• Vohra, Anita
• Lane, Sarah
• Parker, Dann L.
• Cornella Taracido, Ivan
• Johns, Douglas G.
• Beerens, Manu
• MacRae, Calum A.
• Caldwell, John P.
• Sorota, Steve
• Asnani, Aarti
• Peterson, Randall T.

Titel

Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

Ist Teil von

• Chembiochem : a European journal of chemical biology, 2020-07, Vol.21 (13), p.1780-1780

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Cyp1 inhibition prevents doxorubicin‐induced cardiomyopathy in a zebrafish heart‐failure model. Doxorubicin, a potent chemotherapy drug, has a side effect of inducing heart failure. By using a zebrafish doxorubicin‐induced cardiomyopathy model for in vivo small‐molecule screening, the cytochrome P450 family (CYP1) was identified as a candidate therapeutic target for clinical cardioprotection. More information can be found in the full paper by R. T. Peterson et al.