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Reversed Cation Selectivity of G 8 -Octamer and G 16 -Hexadecamer towards Monovalent and Divalent Cations
Ist Teil von
Chemistry, an Asian journal, 2020-04, Vol.15 (7), p.1030-1034
Ort / Verlag
Germany
Erscheinungsjahr
2020
Quelle
Wiley Online Library
Beschreibungen/Notizen
A reverse-binding-selectivity between monovalent and divalent cations was observed for two different self-assembly G
-hexadecamer and G
-octamer systems. The dissociation constant between G
-quadruplex and monomer was calculated via VT-
H NMR experiments. Quantitative energy profiles revealed entropy as the key factor for the weaker binding toward Ba
compared with K
in the G
-octamer system despite stronger ion-dipole interactions. This study is the first direct comparison of the G
-quartet binding affinity between mono and divalent cations and will benefit future applications of G-quadruplex-related research. Further competition experiments between the G
-octamer and 18-crown-6 with K
demonstrated the potential of this G
system as a new potassium receptor.