Details

Autor(en) / Beteiligte

• He, Ying
• Zhang, Yanbin
• Wojtas, Lukasz
• Akhmedov, Novruz G
• Pan, Qinhe
• Guo, Hao
• Shi, Xiaodong

Titel

Reversed Cation Selectivity of G 8 -Octamer and G 16 -Hexadecamer towards Monovalent and Divalent Cations

Ist Teil von

• Chemistry, an Asian journal, 2020-04, Vol.15 (7), p.1030-1034

Ort / Verlag

Germany

Erscheinungsjahr

2020

Quelle

Wiley Online Library

Beschreibungen/Notizen

• A reverse-binding-selectivity between monovalent and divalent cations was observed for two different self-assembly G -hexadecamer and G -octamer systems. The dissociation constant between G -quadruplex and monomer was calculated via VT- H NMR experiments. Quantitative energy profiles revealed entropy as the key factor for the weaker binding toward Ba compared with K in the G -octamer system despite stronger ion-dipole interactions. This study is the first direct comparison of the G -quartet binding affinity between mono and divalent cations and will benefit future applications of G-quadruplex-related research. Further competition experiments between the G -octamer and 18-crown-6 with K demonstrated the potential of this G system as a new potassium receptor.