Details

Autor(en) / Beteiligte

• Harenberg, Johannes H.
• Weidmann, Niels
• Knochel, Paul

Titel

Cover Picture: Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow (Angew. Chem. Int. Ed. 30/2020)

Ist Teil von

• Angewandte Chemie International Edition, 2020-07, Vol.59 (30), p.12225-12225

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Metalation of functionalized (hetero)arenes with KDA (potassium diisopropylamide)/TMEDA to give the corresponding potassium organometallics was performed using a commercial continuous flow set‐up. In their Communication on page 12321, P. Knochel et al. show that trapping with various electrophiles gives polyfunctionalized (hetero)aromatics in good yields. The flow procedure was extended to the lateral metalation of methyl‐substituted (hetero)arenes resulting in benzylic potassium organometallics, which were trapped with various electrophiles.