Details

Autor(en) / Beteiligte

• Grover, Rajesh K.
• Pond, Stephanie J. K.
• Cui, Qizhi
• Subramaniam, Prem
• Case, David A.
• Millar, David P.
• Wentworth Jr, Paul

Titel

Inside Cover: O-Glycoside Orientation Is an Essential Aspect of Base J Recognition by the Kinetoplastid DNA-Binding Protein JBP1 (Angew. Chem. Int. Ed. 16/2007)

Ist Teil von

• Angewandte Chemie (International ed.), 2007-04, Vol.46 (16), p.2728-2728

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2007

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Protein recognition of DNA is key to the control of genome expression within living cells. Kinetoplastid parasites like those in the background possess the protein JBP1, which binds to double‐stranded DNA containing the glycosylated base shown (nucleoside dJ). In their Communication on page 2839 ff., P. Wentworth, Jr. et al. analyze the binding and find that JBP1 recognizes a critical edge‐on conformation of the pyranosyl ring of nucleoside dJ. These results are important for the development of new biological targets for antiparasitic drugs.