Details

Autor(en) / Beteiligte

• Li, Jiao‐Zhe
• Mei, Lan
• Cai, Xue‐Er
• Zhang, Can‐Can
• Cao, Ting‐Ting
• Huang, Xun‐Jie
• Liu, Yi‐Lin
• Wei, Wen‐Ting

Titel

Transition‐Metal‐Free Radical Cyclization of 2‐Arylbenzoimidazoles with Unactivated Alkanes via C(sp3)−H Functionalizations in Aqueous Media

Ist Teil von

• Advanced synthesis & catalysis, 2022-06, Vol.364 (12), p.2080-2085

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Here we present a transition‐metal‐free radical cyclization of 2‐arylbenzoimidazoles with unactivated alkanes. By using di‐tert‐butyl peroxide (DTBP) to promote the C(sp3)−H bond functionalization, this approach enables assembly of various benzimidazo[2,1‐a]isoquinolin‐6(5H)‐ones in aqueous media. This strategy can not only well tolerate a wide range of cyclic alkanes, straight‐chain alkanes, toluene derivatives, as well as pharmaceutical molecule eudesmol, but also provides an approach for the functionalization of unactivated C(sp3)−H bonds in aqueous media under transition‐metal‐free systems.