Details

Autor(en) / Beteiligte

• Chen, Pu
• Xie, Jun
• Chen, Zan
• Xiong, Bi‐Quan
• Liu, Yu
• Yang, Chang‐An
• Tang, Ke‐Wen

Titel

Visible‐Light‐Mediated Nitrogen‐Centered Radical Strategy: Preparation of 3‐Acylated Spiro[4,5]trienones

Ist Teil von

• Advanced synthesis & catalysis, 2021-09, Vol.363 (18), p.4440-4446

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• A nitrogen‐centered radical strategy for the preparation of 3‐acylated spiro[4,5]trienones via visible‐light‐mediated acylation/ipso‐cyclization of alkynes with acyl oxime esters is reported. The alkyl‐ and aryl‐substituted acyl radicals, which generate from the cleavage of carbon‐carbon σ‐bonds in acyl oxime esters via nitrogen‐centered radical pathway, attack the carbon‐carbon triple bonds in propiolamides and then undergo ipso‐cyclization. This method provides a way for the construction of 3‐acyl‐substituted spiro[4,5]trienones, which can introduce aryl‐ or alkyl‐substituted acyl into spiro[4,5]trienone skeletons.