Details

Autor(en) / Beteiligte

• Gao, Dingding
• Wang, Feng
• Liu, Xing‐Yu
• Feng, Kai‐Rui
• Zhao, Jia‐Ying
• Wang, Yu‐Hui
• Yang, Xiao‐Di
• Tian, Ping
• Lin, Guo‐Qiang

Titel

Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)‐Catalyzed Hydroarylation and Relay Thiophene‐Promoted Intramolecular [2+2] Cycloaddition

Ist Teil von

• Advanced synthesis & catalysis, 2020-10, Vol.362 (20), p.4384-4390

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)‐catalyzed hydroarylation and relay thiophene‐promoted intramolecular [2+2] cycloaddition. This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene‐promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition. Moreover, the resulting polycyclic products displayed potent anti‐cancer activities against breast cancer cell lines MDA‐MB‐468.