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DNA damage in leukocytes and buccal and nasal epithelial cells of individuals exposed to air pollution in Mexico City
Environmental and molecular mutagenesis, 1997, Vol.30 (2), p.147-152
Valverde, Mahara
López, Maria del Carmen
López, Irma
Sánchez, Ivonne
Fortoul, Teresa Imelda
Ostrosky-Wegman, Patricia
Rojas, Emilio
1997
Details
Autor(en) / Beteiligte
Valverde, Mahara
López, Maria del Carmen
López, Irma
Sánchez, Ivonne
Fortoul, Teresa Imelda
Ostrosky-Wegman, Patricia
Rojas, Emilio
Titel
DNA damage in leukocytes and buccal and nasal epithelial cells of individuals exposed to air pollution in Mexico City
Ist Teil von
Environmental and molecular mutagenesis, 1997, Vol.30 (2), p.147-152
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1997
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
There is an increased interest in using biological markers to monitor individuals for possible exposure to environmental toxicants. Test systems which permit the sensitive detection of DNA damage and DNA repair are critically important in such studies. The single cell gel electrophoresis (SCG) assay is a rapid and a sensitive method for the evaluation of DNA damage at the single cell level, providing information on the occurrence of DNA single‐strand breaks and alkali labile sites using alkaline conditions. In this study, the differences in the basal level of DNA damage between young adults from the south (exposed principally to high levels of ozone) and young adults from the north (exposed principally to hydrocarbons and particles) of Mexico City were investigated by the SCG assay using three different cell types (leukocytes and nasal and buccal epithelial cells). We found an increased DNA migration in blood leukocytes and nasal cells from individuals who live in the southern part of the city compared to those living in the northern part; however, no differences were observed for buccal epithelial cells. These results show the feasability of using the SCG assay to evaluate DNA damage in different tissues and its great potential for use in the monitoring of humans potentially exposed to genotoxic pollutants. Environ. Mol. Mutagen. 30:147–152, 1997 © 1997 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0893-6692
eISSN: 1098-2280
DOI: 10.1002/(SICI)1098-2280(1997)30:2<147::AID-EM7>3.0.CO;2-K
Titel-ID: cdi_crossref_primary_10_1002__SICI_1098_2280_1997_30_2_147__AID_EM7_3_0_CO_2_K
Format
–
Schlagworte
Adult
,
Air
,
Air Pollutants - toxicity
,
Biological and medical sciences
,
Cheek
,
comet assay
,
DNA damage
,
DNA Damage - drug effects
,
Environmental pollutants toxicology
,
Epithelium - drug effects
,
Female
,
Genetic Techniques
,
Health Status
,
human monitoring
,
Humans
,
Leukocytes - drug effects
,
Male
,
Medical sciences
,
Mexico
,
Nasal Mucosa - drug effects
,
ozone
,
Ozone - adverse effects
,
single-cell gel electrophoresis
,
Toxicology
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