UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 20 von 58
Datensatz exportieren als...
BibTeX
Investigation of the genes for RET and its ligand complex, GDNF/GFRα-1, in small cell lung carcinoma
Genes chromosomes & cancer, 1998-04, Vol.21 (4), p.326-332
Mulligan, Lois M.
Timmer, Tineke
Ivanchuk, Stacey M.
Campling, Barbara G.
Young, Leah C.
Rabbitts, Pamela H.
Sundaresan, Vasi
Hofstra, Robert M. W.
Eng, Charis
1998
Details
Autor(en) / Beteiligte
Mulligan, Lois M.
Timmer, Tineke
Ivanchuk, Stacey M.
Campling, Barbara G.
Young, Leah C.
Rabbitts, Pamela H.
Sundaresan, Vasi
Hofstra, Robert M. W.
Eng, Charis
Titel
Investigation of the genes for RET and its ligand complex, GDNF/GFRα-1, in small cell lung carcinoma
Ist Teil von
Genes chromosomes & cancer, 1998-04, Vol.21 (4), p.326-332
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1998
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
RET is a receptor tyrosine kinase expressed in neuroendocrine cells and in tumors of these cell types. RET activation may be mediated by a ligand complex comprising glial cell line‐derived neurotrophic factor (GDNF) and GDNF family receptor alpha‐1 (GFRα‐1). Activating RET mutations are found in the inherited cancer syndrome multiple endocrine neoplasia type 2 and in a subset of the related sporadic tumors, medullary thyroid carcinoma and pheochromocytoma, both being derived from neuroendocrine tissues. In one small study, mutations were identified in another tumor with neuroendocrine features, small cell lung carcinoma (SCLC). To determine whether RET mutations contribute to the pathogenesis of SCLC, we examined a panel of 54 SCLC cell lines. No mutations were identified in RET exons 10, 11, and 13–16, regions previously implicated in SCLC or other neuroendocrine tumors. We further examined the expression pattern of RET and the genes encoding the components of its ligand complex GDNF and GFRα‐1, in 21 SCLC lines by using RT‐PCR. Although we found no consistent pattern of expression for these three genes, RET was expressed in 57% of SCLC lines. Thus, although RET mutations appear unlikely to be an important step in the tumorigenesis of SCLC, the frequent expression of this gene suggests that RET may have a mitogenic role in a subset of SCLC cell lines. Genes Chromosomes Cancer 21:326–332, 1998. © 1998 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0
Titel-ID: cdi_crossref_primary_10_1002__SICI_1098_2264_199804_21_4_326__AID_GCC6_3_0_CO_2_0
Format
–
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX