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BibTeX
SNAP-25 requirement for dendritic growth of hippocampal neurons
Journal of neuroscience research, 1999-06, Vol.56 (5), p.539-546
Grosse, Gisela
Grosse, Johannes
Tapp, Rosemarie
Kuchinke, Jörg
Gorsleben, Martin
Fetter, Ingmar
Höhne-Zell, Barbara
Gratzl, Manfred
Bergmann, Mathias
1999
Details
Autor(en) / Beteiligte
Grosse, Gisela
Grosse, Johannes
Tapp, Rosemarie
Kuchinke, Jörg
Gorsleben, Martin
Fetter, Ingmar
Höhne-Zell, Barbara
Gratzl, Manfred
Bergmann, Mathias
Titel
SNAP-25 requirement for dendritic growth of hippocampal neurons
Ist Teil von
Journal of neuroscience research, 1999-06, Vol.56 (5), p.539-546
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
1999
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which form processes during the first week in vitro. We detected a key component of regulated exocytosis, SNAP‐25 (synaptosomal associated protein of 25 kDa), in axons and axonal terminals as well as in dendrites identified by the occurrence of the dendritic markers transferrin receptor and MAP2. Selective inactivation of SNAP‐25 by botulinum neurotoxin A (BoNTA) resulted in inhibition of axonal growth and of vesicle recycling in axonal terminals. In addition, dendritic growth of hippocampal pyramidal and granule neurons was significantly inhibited by BoNTA. In contrast, cleavage of synaptobrevin by tetanus toxin had an effect on neither axonal nor dendritic growth. Our observations indicate that SNAP‐25, but not synaptobrevin, is involved in constitutive axonal growth and dendrite formation by hippocampal neurons. J. Neurosci. Res. 56:539–546, 1999. © 1999 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0360-4012
eISSN: 1097-4547
DOI: 10.1002/(SICI)1097-4547(19990601)56:5<539::AID-JNR9>3.0.CO;2-Y
Titel-ID: cdi_crossref_primary_10_1002__SICI_1097_4547_19990601_56_5_539__AID_JNR9_3_0_CO_2_Y
Format
–
Schlagworte
Animals
,
Axons - physiology
,
botulinum neurotoxin A
,
Botulinum Toxins, Type A - pharmacology
,
Cells, Cultured
,
dendrite
,
Dendrites - drug effects
,
Dendrites - physiology
,
Endocytosis - drug effects
,
Exocytosis - drug effects
,
Fetus
,
Hippocampus - cytology
,
Hippocampus - drug effects
,
Hippocampus - physiology
,
Membrane Proteins
,
Mice
,
Mice, Inbred Strains
,
Microtubule-Associated Proteins - metabolism
,
mouse hippocampal neurons
,
Nerve Tissue Proteins - metabolism
,
Neurons - physiology
,
Presynaptic Terminals - drug effects
,
Presynaptic Terminals - physiology
,
Pyramidal Cells - cytology
,
Pyramidal Cells - physiology
,
Receptors, Transferrin - metabolism
,
SNAP-25
,
Synaptic Vesicles - physiology
,
synaptobrevin
,
Synaptosomal-Associated Protein 25
,
tetanus toxin
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