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Characterization of Mercapturic Acids by Three Different Mass Spectrometric Methods
Rapid communications in mass spectrometry, 1997-05, Vol.11 (8), p.931-935
Eškinja, Mirela
Zöllner, Peter
Linnemayr, Katharina
Mâk, Marianna
Schmid, Erich R.
1997
Details
Autor(en) / Beteiligte
Eškinja, Mirela
Zöllner, Peter
Linnemayr, Katharina
Mâk, Marianna
Schmid, Erich R.
Titel
Characterization of Mercapturic Acids by Three Different Mass Spectrometric Methods
Ist Teil von
Rapid communications in mass spectrometry, 1997-05, Vol.11 (8), p.931-935
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
1997
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
The determination of mercapturic acids, as metabolic end‐products of an important pathway in the biotransformation of xenobiotics, in human urine is becoming a standard tool for the biomonitoring of populations exposed to potential mutagens and carcinogens. Mass spectrometric methods permit the direct identification and characterization of these substances without a previous derivatization step. In this work, N‐acetylcysteine conjugates of synthetic origin were characterized by three different mass spectrometric methods: matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry, positive and negative californium‐252 plasma desorption mass spectrometry (PD‐MS) and fast‐atom bombardment (FAB) mass spectrometry. For PD‐MS, samples were prepared by the spin deposition technique on plain aluminium targets. α‐Cyano‐4‐hydroxycinnamic acid and 2,5‐dihydroxybenzoic acid were used as MALDI matrices and glycerol as a matrix for FAB. Complementary structural information on the N‐acetylcysteine moiety and the xenobiotic moiety was obtained through PD‐MS and FAB spectra. All three techniques could be used for relative molecular mass determination. The spectra exhibited protonated molecules [M + H]+ or [M + Na]+ ions with high abundance. MALDI was the most sensitive among the three tested methods. © 1997 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-4198
eISSN: 1097-0231
DOI: 10.1002/(SICI)1097-0231(199705)11:8<931::AID-RCM938>3.0.CO;2-L
Titel-ID: cdi_crossref_primary_10_1002__SICI_1097_0231_199705_11_8_931__AID_RCM938_3_0_CO_2_L
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