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Pre‐natal and peri‐natal exposures and risk of testicular germ‐cell cancer
International journal of cancer, 2000-08, Vol.87 (3), p.438-443
Weir, Hannah K.
Marrett, Loraine D.
Kreiger, Nancy
Darlington, Gerarda A.
Sugar, Linda
2000
Details
Autor(en) / Beteiligte
Weir, Hannah K.
Marrett, Loraine D.
Kreiger, Nancy
Darlington, Gerarda A.
Sugar, Linda
Titel
Pre‐natal and peri‐natal exposures and risk of testicular germ‐cell cancer
Ist Teil von
International journal of cancer, 2000-08, Vol.87 (3), p.438-443
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
The present case‐control study was undertaken to investigate the association between exposure to maternal hormones and risk of testicular germ‐cell cancer by histologic subgroups. Cases were males, aged 16 to 59 years, diagnosed with testicular germ‐cell cancer in Ontario between 1987 and 1989. Histologic review was performed on all eligible cases for the purpose of categorizing cases as seminoma or non‐seminoma (the latter classified 2 ways, with and without tumors containing seminoma). Risk factor data were collected on 502 cases, 346 case mothers, 975 age‐matched controls, and 522 control mothers. Exogenous hormone exposure was associated with elevated risk (OR = 4.9, 95% CI 1.7–13.9). Several additional risk factors were associated with risk of testicular cancer: bleeding and threatened miscarriage (OR = 0.6, 95% CI 0.3–1.0), maternal cigarette smoking (12+ cigarettes/day OR = 0.6, 95% CI 0.4–1.0). pre‐term birth (OR = 1.6, 95% CI 1.0–2.5), and treatment for undescended testicle (OR = 8.0, 95% CI 3.2–20.0). First births were associated with elevated risk (OR = 1.7, 95% CI 1.0–2.8) among mothers below the age of 24 years at conception. There was little evidence that risk factors differed by histologic subgroup. We found evidence that exposure to maternal hormones, particularly estrogens, is associated with testicular germ‐cell cancer risk. Not only does exposure to elevated levels (exogenous hormone use, pre‐term birth, and first births among young mothers) increase risk but also exposure to relatively lower levels (heavy cigarette consumption and, perhaps, bleeding and threatened miscarriage) may decrease cancer risk. Int. J. Cancer 87:438–443, 2000. © 2000 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/1097-0215(20000801)87:3<438::AID-IJC20>3.0.CO;2-1
Titel-ID: cdi_crossref_primary_10_1002_1097_0215_20000801_87_3_438__AID_IJC20_3_0_CO_2_1
Format
–
Schlagworte
Abortion, Threatened - epidemiology
,
Adolescent
,
Adult
,
Age Factors
,
Alcohol Drinking - adverse effects
,
Biological and medical sciences
,
Birth Order
,
Body Weight
,
Case-Control Studies
,
Cryptorchidism - epidemiology
,
Cryptorchidism - surgery
,
Environmental Exposure
,
Estrogens - adverse effects
,
Female
,
Germinoma - epidemiology
,
Germinoma - etiology
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Infant, Newborn
,
Infant, Premature
,
Male
,
Male genital diseases
,
Medical sciences
,
Middle Aged
,
Odds Ratio
,
Ontario - epidemiology
,
Parity
,
Pregnancy
,
Pregnancy Complications - epidemiology
,
Prenatal Exposure Delayed Effects
,
Risk Factors
,
Seminoma - epidemiology
,
Seminoma - etiology
,
Smoking
,
Surveys and Questionnaires
,
Testicular Neoplasms - epidemiology
,
Testicular Neoplasms - etiology
,
Tumors
,
Vomiting - epidemiology
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