Details

Autor(en) / Beteiligte

• Vatnehol, Svein Are Sirirud
• Hol, Per Kristian
• Bjørnerud, Atle
• Amiry-Moghaddam, Mahmood
• Haglerød, Camilla
• Storås, Tryggve Holck

Titel

Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen

Ist Teil von

• Magma (New York, N.Y.), 2020, Vol.33 (3), p.447-453

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2020

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• Objective To investigate the sensitivity of modified Look–Locker inversion recovery (MOLLI) to measure changes in dissolved oxygen (DO) concentrations in water samples and to calculate sequence-specific relaxivity ( r 1 m ) and limit of detection (LOD). Materials and methods Ten water samples with a range of DO concentrations were scanned at 3 T using two variations of MOLLI schemes. Using linear regression the r 1 of DO was estimated from the measured DO concentrations and T 1 relaxation rates ( R 1 ). The results were combined with previously reported values on in vivo stability measures of the MOLLI sequences and used to estimate a LOD. Results DO concentrations ranged from 0.5 to 21.6 mg L −1 . A linear correlation between DO and R 1 was obtained with both MOLLI sequences, with an average correlation coefficient ( R 2 ) 0.9 and an average estimated r 1 ( r ^ 1 ) of 4.45 × 10 −3  s −1  mg −1  L. Estimated LOD was ≈ 10 mg L −1 . Conclusion MOLLI T 1 -mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an r ^ 1 in the range 4.18–4.8 × 10 −3  s −1  mg −1  L and a corresponding LOD for dissolved oxygen of approximately 10 mg L −1 . MOLLI-based T 1 mapping may be a useful non-invasive tool for quantification of in vivo changes of DO concentration during oxygen challenges.