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T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease
Ist Teil von
中国科学：生命科学英文版, 2016 (12), p.1282-1289
Erscheinungsjahr
2016
Link zum Volltext
Quelle
SpringerLink Journals - AutoHoldings
Beschreibungen/Notizen
Cell-mediated autoimmunity, particularly that involving autoreactive T cells, participates in mediating anti-glomerular basement membrane(GBM) disease. However, direct kidney injury mediated by renal infiltrated T cells has not been clearly elucidated in humans. The T cell profile(CD3, CD4, CD8, IL-17, and foxp3) and macrophage(CD68) were examined by immunohistochemistry on renal biopsy tissues from 13 patients with anti-GBM disease. The correlation between cell infiltration and clinical data was also analyzed. We found that the distribution of T cell infiltration was predominant in the peri-glomerular and interstitial areas. CD3~+ T cell infiltratrion around the glomeruli with cellular crescent formations was significantly higher than that around the glomeruli with mild mesangial proliferation. CD8~+ T cells significantly accumulated around the glomeruli with cellular crescents without Ig G deposits compared to those with Ig G deposits. The prevalence of infiltrating CD8~+ T cells was correlated with the percentage of ruptured Bowman’s capsules. In conclusion, cellular immunity may play a crucial role in the inflammatory kidney injury in anti-GBM patients. The periglomerular infiltration of T cells, especially CD8~+ T cells, may participate in the pathogenic mechanism of glomerular damage.