Details

Autor(en) / Beteiligte

• Dawei Ma
• Songtao Niu
• Jinlong Zhao
• Xi Jiang
• Yongwen Jiang
• Xiaojing Zhang
• Tiemin Sun

Titel

A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with （Hetero）aryl Chlorides

Ist Teil von

• 中国化学：英文版, 2017, Vol.35 (11), p.1661-1664

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• （（2S,4R）-4-Hydroxy-N-（2-methylnaphthalen-l-yl）pyrrolidine-2-carboxamide （HMNPC）, an amide derived from 4-hydroxy-L-proline and 2-methyl naphthalen-l-amine, is a powerful ligand for Cu-catalyzed coupling of （het- ero）aryl halides with sulfinic acid salts, allowing for first time the metal-catalyzed coupling of （hetero）aryl chlorides and NaSO2Me. A considerable number of （hetero）aryl chlorides worked well, providing the pharmaceutically im- portant （hetero）aryl methylsulfones in good to excellent yields.