Details

Autor(en) / Beteiligte

• Xin-Yu He Ke Sun Ruo-Shi Xu Jia-Li Tan Cai-Xia Pi Mian Wan Yi-Ran Peng Ling Ye Li-Wei Zheng Xue-Dong Zhou

Titel

Spatial signalling mediated by the transforming growl Factor-β signalling pathway during tooth formation

Ist Teil von

• 国际口腔科学杂志：英文版, 2016 (4), p.199-204

Erscheinungsjahr

2016

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day （E） 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process.