Details

Autor(en) / Beteiligte

• LI Xiao-tong YU Zhong-xiang YAN Rong-qiang MA Ying WANG Hai-yang REN Yong-qiang ZHAO Kai-di HOU Fang-jie FAN Shu-xin ZHANG Jun-yi

Titel

ADP-P2Y12 receptor antagonist sequential therapy for antiplatelet strategy in acute myocardial infarction patients with clobidogrel hyporesponse

Ist Teil von

• 岭南心血管病杂志：英文版, 2015, Vol.16 (4), p.215-220

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background Compared to clopidogrel, Ticagrelor significantly reduces the risk of cardiovascular events in patients with acute myocardial infarction （AMI） however increases the incidence of bleeding and the risk of fatal intracranial hemorrhage. In this study, we screened the AMI patients with clopidogrel resistence, and determined whether ticagrelor sequential therapy could reduce the risk of cardiovascular events and bleeding risk. Methods A total of 319 AMI patients were enrolled in this prospective clinical study. The platelet inhibition rates in adenosine 5＇-diphosphate （ADP） pathways were measured by a thrombelastography （TEG） system. The patients with clopidogrel resistance were divided into Ticagrelor sequential therapy group （ticagrelor for 3 months and clopidogrel for 9 months, n=143） and Clopidogrel group （clopidogrel for 12 months, n=176）. The risk of major adverse cardiac events （MACE） and the safety end points at 1-year follow-up were analyzed. Results The rates of stent thrombosis （ST）（2.1% vs. 8.0%, P=0.017）or MI （2.8% vs. 10.2%, P=0.009）were lower in the ticagrelor sequential therapy group than in the clopidogrel group. Dyspnea was more often in the ticagrelor sequential therapy group than in the clopidogrel group （17.5% vs. 4.5%, P〈0.001）. No significant difference in the rate of major bleeding was found between the groups （3.4% vs. 3.9%, P=0.528）. Conclusions In AMI patients with hyporesponsiveness to clobidogrel ticagrelor sequential therapy group significantly decreased the rates of ST and MI without increased risk of major bleeding as compared with clopidolgrel.