Details

Autor(en) / Beteiligte

• Chen Hu Tian Xia Ying Gong Xin Wang Ruan-qing Liu Quan-yuan Zhang Chang-feng Yi Zu-shun Xu Ding-zong Guo

Titel

Emulsifier-free Emulsion Polymerized Poly（MMA-HEMA- Eu（AA）3Phen）/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging

Ist Teil von

• 高分子科学：英文版, 2016 (2), p.135-146

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Integration of biocompatibility with superparamagnetic Fe3O4 nanoparticles and luminescence rare earth complexes Eu（AA）3Phen was carried out to form bifunctional nanospheres for using in bioimaging applications. The nanospheres Poly（MMA-HEMA-Eu（AA）3Phen）/Fe3O4 exhibit magnetic and fluorescent properties that are favorable for the use in drug delivery, magnetic separation and MR imaging for biomedical research. The TEM and SEM studies reveal that the bifunctional nanospheres have core-shell structure, in a spherical shape with a size ranging from 140 nm to 180 nm. In MRI experiments, a clear negative contrast enhancement in T2 images and the r2 reaches 568.82 （mmol·L^-1）^-1·s^-1. In vivo magnetic and fluorescence resonance imaging results suggest the nanospheres are able to preferentially accumulate in liver and spleen tissues to allow dual-modal detection of cancer cells in a living body.