Details

Autor(en) / Beteiligte

• SHEN Cheng-Ying DAI Ling SHEN Bao-De ZHOU Xu BAI Jin-Xia XU He LV Qing-Yuan HAN Jin YUAN Hai-Long

Titel

Nanostructured lipid carrier based topical gel of Ganoderma TriterDenoids for frostbite treatment

Ist Teil von

• 中国天然药物, 2015, Vol.13 (6), p.454-460

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The objective of this study was to prepare nanostmctured lipid carder （NLC）-based topical gel of Ganoderma Triterpenoids （GTs） and evaluate their effects on frostbite treatment. GT-NLCs was prepared by the high pressure homogenization method and then characterized by morphology and analyses of particle size, zeta potential, entrapment efficiency （EE）, and drug loading （DL）. The NLCs was suitably gelled for skin permeation studies in vitro and pharmacodynamic evaluation in vivo, compared with the GT emulgel. The GT-NLC remained within the colloidal range and was uniformly dispersed after suitably gelled by carbopol preparation. Transmission electron microscopy （TEM） study showed GT-NLCs was spherical in shape. The EE （%） and DL （%） could reach up to （81.84 ± 0.60）% and （2.13 ± 0.12）%, respectively. The result of X-ray diffractograms （XRD） showed that GTs were in an amorphous state in the NLC-gel. In vitro permeation studies through rat skin indicated that the amount of GTs permeated through skin of GT-NLCs aft