中国化学快报：英文版, 2014 (4), p.541-544
2014
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Details
- Autor(en) / Beteiligte
- Titel
- 6,7-seco-ent-Kaurane diterpenoids from lsodon sculponeatus and their bioactivity
- Ist Teil von
- 中国化学快报：英文版, 2014 (4), p.541-544
- Erscheinungsjahr
- 2014
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- One new 6,7-seco-ent-kaurane diterpenoid, sculponin T （1）, was isolated from the aerial parts of lsodon sculponeatus, along with four known analogs, sculponeatin J （2）, sculponeatin K （3）, sculponeatin C （4）, and sculponeatin Q （5）. Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 μmol/L.