中国科学：化学英文版, 2013 (9), p.1293-1300
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Stereoselective C（sp^3）-C（sp^2） Negishi coupling of （2-amido-1-phenylpropyl）zinc compounds through the steric control of β-amido group
- Ist Teil von
- 中国科学：化学英文版, 2013 (9), p.1293-1300
- Erscheinungsjahr
- 2013
- Quelle
- SpringerNature Journals
- Beschreibungen/Notizen
- A controllable diastereoselective C（sp2）-C（sp3） Negishi coupling reaction of secondary benzylic zinc reagents with aryl bromides has been demonstrated for the first time, forming medicinally important 1-arylphenylethylamines. In the presence of Pd（OAc） 2 and S-phos, open-chain （2-amido-1-phenylethyl）zinc reagents bearing a -NHAc or NHCHO group underwent cross-coupling reaction to give syn 1-arylphenylethylamine as the major products, whereas the zinc reagents bearing a sterically hindered-NHCOC（CH3）2 OTBS group specifically yielded anti 1-arylphenylethylamines.