Details

Autor(en) / Beteiligte

• Lu LI Tao WU Cong WEI Jian-ke HAN Zhen-hua JIA Yi-ling WU Lei-ming REN

Titel

Exhaustive swimming differentially inhibits P2X1 receptor- and al-adrenoceptor-mediated vasoconstriction in isolated rat arteries

Ist Teil von

• 中国药理学报：英文版, 2012, Vol.33 (2), p.221-229

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aim： To investigate the effects of exhaustive swimming exercise on P2X1 receptor- and （xl-adrenoceptor-mediated vasoconstriction of different types of arteries in rats. Methods： Male Wistar rats were divided into 2 groups： the sedentary control group （SCG） and the exhaustive swimming exercise group （ESEG）. The rats in the ESEG were subjected to a swim to exhaustion once a day for 2 weeks. Internal carotid, caudal, pulmonary, mes- enteric arteries and aorta were dissected out. Isometric vasoconstrictive responses of the arteries to a,[3-methylene ATP （（x,t3-MeATP） or noradrenaline （NA） were recorded using a polygraph. Results： The exhaustive swimming exercise did not produce significant change in the ECso values of a,[3-MeATP or NA in vasoconstric- tive response of most of the arteries studied. The exhaustive swimming exercise inhibited the vasoconstrictive responses to P2X1 receptor activation in the internal carotid artery, whereas it reduced the maximal vasoconstrictive responses to al-adrenoceptor stimu- lation in the caudal, pulmonary, mesenteric arteries and aorta. The rank order of the reduction of the maximal vasoconstriction was as follows： mesenteric, pulmonary, caudal, aorta. Conclusion： Exhaustive swimming exercise differentially affects the P2X1 receptor- and al-adrenoceptor-regulated vasoconstriction in internal carotid artery and peripheral arteries. The ability to preserve purinergic vasoconstriction in the peripheral arteries would be useful to help in maintenance of the basal vascular tone during exhaustive swimming exercise.