Ai zheng, 2011, Vol.30 (1), p.62-68
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Expression and unique functions of four nuclear factor of activated T cells isoforms in non-small cell lung cancer
- Ist Teil von
- Ai zheng, 2011, Vol.30 (1), p.62-68
- Erscheinungsjahr
- 2011
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Nuclear factor of activated T cells （NFAT） is an important family of transcription factors that can be activated by calmodulin and calcineurin in human cells. To investigate the expression and clinical significance of NFAT isoforms and calcineurin in non-small cell lung cancer （NSCLC）, we collected tumor and adjacent normal tissues from 159 NSCLC patients and assembled them in a tissue microarray. Protein levels of NFAT1, NFAT2, NFAT3, NFAT4, and calcineurin were determined using immunohistochemistry. Correlations between NFAT and calcineurin expression and clinicopathologic characteristics were analyzed. We found that the positive rates of NFAT1 （52.8%, 84/159）, NFAT2 （11.3%, 18/159）, NFAT3 （28.3%, 45/ 159）, NFAT4 （47.2%, 75/159）, and calcineurin （47.8%, 76/159） expression were significantly higher in tumor tissues than in adjacent normal lung tissues （P 〈 0.001）, respectively. The positive rate of NFAT1 expression was significantly higher in patients with adenocarcinoma （63.5%, 47/74） than in those with squ