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Inhibitory Effect of Fluorocitrate on the Proliferation of Cultured Glioblastomas G422 Cells
Ist Teil von
Dōngwùxué yánjiū, 2009-06, Vol.29 (4)
Ort / Verlag
China: Kunming Institute of Zoology, Chinese Academy of Sciences
Erscheinungsjahr
2009
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
In the present study, the effects of fluorocitrate on the proliferation
of cultured glioblastomas G422 cells were investigated. Proliferation
of glioblastomas G422 cells was measured by MTT assay at 36 h, 48 h and
60 h after fluorocitrate (0.0025 mmol/L, 0.005 mmol/L, 0.01 mmol/L,
0.025 mmol/L and 0.1 mmol/L) treatment. Our results showed that: (1)
Fluorocitrate inhibited the proliferation of glioblastomas G422 cells
in a dose dependent manner; (2) The inhibition rate increased with
treatment time at high concentrations of fluorocitrate (0.01 mmol/L,
0.025 mmol/L and 0.1 mmol/L); (3) The inhibition rate did not increase
with treatment time at low concentrations of fluorocitrate (0.0025
mmol/L and 0.005 mmol/L). This study indicated that fluorocitrate
inhibited the proliferation of glioma cells as a function of
fluorocitrate concentration and treatment time.