Details

Autor(en) / Beteiligte

• Chen, Xiangyu

Titel

New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

Auflage

1

Ort / Verlag

Singapore: Springer Singapore Pte. Limited

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and a,-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of -substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging -substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via y-addition. Highly enantiopure tetrahydropyridazinones and y-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available a,-unsaturated carboxylic acids were first successfully employed to generate the a,-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.