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Babies of women with diabetes are nearly five times more likely to be stillborn and almost three times more likely to die in the first three months. The incidence of gestational diabetes mellitus in the U.S. is high—between 3 and 7 percent—and rising. The condition is often complicated by other risk factors such as obesity and heart disease.
The Textbook of Diabetes and Pregnancy presents a comprehensive review of the science, clinical management, and medical implications of gestational diabetes mellitus, a condition with serious consequences that is on the increase in all developed societies. This new edition supports the latest initiatives and strategies of the International Federation of Gynecology and Obstetrics (FIGO) and adds chapters on noncommunicable diseases, obesity, bariatric surgery, and epidemiology outside Western cultures.
Written by a cadre of experts, the book provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy.
Introduction: Merging the Legacies and Hypotheses: Maternal Medicine Meets Fetal Medicine Moshe Hod, Kypros Nicolaides, Hamutal Meiri, and Nicky Lieberman
History of Diabetic Pregnancy David R. Hadden
Metabolism in Normal Pregnancy Emilio Herrera and Henar Ortega-Senovilla
Intermediary Metabolism in Pregnancies Complicated by Gestational Diabetes Bartolomé Bonet, María Bonet-Alavés, and Isabel Sánchez-Vera
Nutrient Delivery and Metabolism in the Fetus William W. Hay, Jr., Paul J. Rozance, Stephanie R. Wesolowski, and Laura D. Brown
Pathogenesis of Gestational Diabetes Mellitus Yariv Yogev
Autoimmunity in Gestational Diabetes Mellitus Alberto de Leiva, Dídac Mauricio, and Rosa Corcoy
Epidemiology of Gestational Diabetes Mellitus Yariv Yogev, Avi Ben Haroush, Moshe Hod, and Jeremy Oats
Genetics of Diabetic Pregnancy Komal Bajaj and Susan J. Gross
Animal Models in Diabetes and Pregnancy Research Catherine Yzydorczyk, Delphine Mitanchez, and Umberto Simeoni
Pathologic Abnormalities of Placental Structure and Function in Diabetes Rhonda Bentley-Lewis, Maria Rosaria Raspollini, and Drucilla Roberts
The Great Obstetric Syndromes: The Roots of Disease Rinat Gabbay-Benziv and Ahmet A. Baschat
Placental Origins of Diabesity and the Origin of Preeclampsia Gernot Desoye and Berthold Huppertz
Diagnosis of Gestational Diabetes Mellitus Donald R. Coustan and Boyd E. Metzger
Cost-Effectiveness of Screening and Management Programs for Gestational Diabetes Mellitus Louise K. Weile, James G. Kahn, Elliot Marseille, and Nicolai Lohse
Changing Health Policy: From Study to National Policy Ofra Kalter-Leibovici, Nicky Lieberman, Ronni Gamzu, and Moshe Hod
Ideal Weight Gain in Diabetic Pregnancy Gerard H.A. Visser and Harold W. de Valk
Medical Nutritional Therapy for Gestational Diabetes Mellitus Lois Jovanovic
Pharmacologic Treatment of Gestational Diabetes Mellitus: When to Start and What Agent to Use Celeste P. Durnwald and Mark B. Landon
Gestational Diabetes Mellitus: The Consequences of Not Treating Oded Langer
Gestational Diabetes Mellitus in Multiple Pregnancies Matteo Andrea Bonomo and Angela Napoli
Glycemic Goals in Diabetic Pregnancy and Defining a "Good Control": Maternal and Fetal Perspective Liran Hiersch and Yariv Yogev
Insulin Therapy in Pregnancy Lois Jovanovic and John L. Kitzmiller
Use of Oral Hypoglycemic Agents in Pregnancy Oded Langer
The Drug Dilemma of Oral Antidiabetic Agents in Pregnancy: Metformin Yoel Toledano, Moshe Zloczower, and Nicky Lieberman
Facing the Noncommunicable Diseases’ Global Epidemic: The Battle of Prevention Starts In Utero the FIGO Challenge Luis Cabero and Sabaratnam Arulkumaran
Links between Maternal Health and Noncommunicable Diseases Anil Kapur
Diabetic Pregnancy in the Developing World Eran Hadar, Eran Ashwal, and Moshe Hod
Managing Diabetic Pregnancy in China Huixia Yang, Weiwei Zhu, and Rina Su
Gestational Diabetes Mellitus, Obesity, and Pregnancy Outcomes Harold David McIntyre, Marloes Dekker-Nitert, Helen Lorraine Graham Barrett, and Leonie Kaye Callaway
Obesity Versus Glycemic Control: Which Contributes More to Adverse Pregnancy Outcome? Amir Aviram and Yariv Yogev
Pharmacological Treatment for the Obese Gestational Diabetes Mellitus Patient Fiona C. Denison and Rebecca M. Reynolds
Role of Exercise in Reducing the Risks of Gestational Diabetes Mellitus in Obese Women Raul Artal
Role of Bariatric Surgery in Obese Women Planning Pregnancy Ron Charach and Eyal Sheiner
Fetal Lung Maturity Gian Carlo Di Renzo, Giulia Babucci, and Graziano Clerici
Monitoring during the Later Stage of Pregnancy and during Labor: Glycemic Considerations Harold W. de Valk and Gerard H.A. Visser
Timing and Mode of Delivery Salvatore Alberico and Gianpaolo Maso
Management of the Macrosomic Fetus Federico Mecacci, Marianna Pina Rambaldi, and Giorgio Mello
Congenital Malformations in Diabetic Pregnancy: Prevalence and Types Paul Merlob
Diabetic Embryopathy in the Preimplantation Embryo Asher Ornoy and Noa Bischitz
Postimplantation Diabetic Embryopathy Ulf J. Eriksson and Parri Wentzel
Fetal Malformations Detected with Magnetic Resonance Imaging in the Diabetic Mother Tuangsit Wataganara
Continuous Glucose Monitoring in Pregnancy Marlon Pragnell and Aaron Kowalski
Insulin Infusion Pumps in Pregnancy Ilana Jaye Halperin and Denice S. Feig
Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy Zoe A. Stewart and Helen R. Murphy
Noninvasive Glucose Monitoring Itai Ben-David and Pierre Singer
Reproduction and Its Impact on Health and Disease Sara Ornaghi and Michael J. Paidas
Diabetes, Pregnancy, and the Developmental Origins of Health and Disease Gerard H.A. Visser and Mark A. Hanson
Interventions to Improve Pregnancy Outcome in Obese Pregnancy: Implications for Mother and Child Rahat Maitland and Lucilla Poston Lifestyle Interventions to Reduce Risk of Diabetes among High-Risk Pregnant and Postpartum Women Lisa Chasan-Taber
Can Fetal Macrosomia Be Predicted and Prevented? Maria Farren and Michael Turner
Hypoglycemia in Diabetic Pregnancy Graziano Di Cianni, Cristina Lencioni, Emilia Lacaria, and Laura Russo
Hypertensive Disorders and Diabetic Pregnancy Jacob Bar, Moshe Hod, and Michal Kovo
Diabetic Retinopathy Nir Melamed and Moshe Hod
Diabetic Nephropathy Elisabeth R. Mathiesen, Lene Ringholm, and Peter Damm
Diabetic Ketoacidosis Annunziata Lapolla and Maria Grazia Dalfrà
Thyroid Disease in Pregnancy Yoel Toledano and Gabriella Solomon
Quality of Care for the Woman with Diabetes at Pregnancy Alberto de Leiva, Rosa Corcoy, Alejandra de Leiva-Pérez, and Eulàlia Brugués
Early Pregnancy Loss and Perinatal Mortality Kinneret Tenenbaum-Gavish, Anat Shmuely, and Moshe Hod
Short-Term Implications of Gestational Diabetes Mellitus: The Neonate Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni
Long-Term Outcomes after Gestational Diabetes Mellitus Exposure in the Offspring Delphine Mitanchez, Catherine Yzydorczyk, and Umberto Simeoni
Metabolomics and Diabetic Pregnancy Angelica Dessì, Roberta Carboni, and Vassilios Fanos
Fetal Growth Restriction: Evidence-Based Clinical Management Eduard Gratacós and Francesc Figueras
"With over 500 pages The Textbook of Diabetes and Pregnancy, now in its third edition, continues to be a comprehensive and detailed review of all aspects of management ranging from the basic science, biochemistry and physiology of pregnancy, to the principles of clinical practice. Spread over fully referenced chapters written by international experts in their field, all aspects of the Impact of diabetes on pregnancy are discussed… It is an excellent reference book and a highly authoritative tome on an increasingly common condition." —Dr Mark Freeman, Glycosmedia
“The book covers everything from the physiology of diabetes in pregnancy to questions about screening and treatment. Each subject is presented as a one-sentence topic and the index is created by listing these 63 topics, which makes the book seem like a list of speakers at a seminar. The chapters do an excellent job of presenting evidence-based guidance.” —Anthony Shanks, MD, Indiana University School of Medicine, Doody’s Book Reviews
Praise for previous editions: "… a comprehensive, thorough book devoted to one of the most common medical conditions to complicate pregnancy….No aspect of diabetes in pregnancy is left unexplored…. a very worthy purchase." —Gilad A. Gross, MD, Washington University School of Medicine in Doody’s Book Reviews "An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring." — New England Journal of Medicine "… an excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem." — Diabetologia
Edited by
Moshe Hod, MD, professor (clinical) of obstetrics and gynecology, and director, Division of Maternal Fetal Medicine, Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tiqva, Israel
Lois G. Jovanovic , MD, clinical professor of medicine, University of Southern California Keck School of Medicine, and adjunct professor of biomolecular science and engineering, University of California-Santa Barbara, and CEO and chief scientific officer, Sansum Diabetes Research Institute, Santa Barbara, USA
Gian Carlo Di Renzo , MD, PhD, professor and chairman, Department of Obstetrics and Gynecology, and director, Centre of Perinatal and Reproductive Medicine, University Hospital, Perugia, Italy
Alberto de Leiva , MD, PhD, Universitat Autònoma de Barcelona, Department of Endocrinology, Diabetes and Nutrition , Hospital de la Santa Creu i Sant Pau; EDUAB-HSP, CIBER-BBN, and Fundación DIABEM , B