Details

Autor(en) / Beteiligte

• Carini, Claudio
• Fidock, Mark
• van Gool, Alain
• Gool, Alain van

Titel

Handbook of Biomarkers and Precision Medicine

Auflage

1

Ort / Verlag

Milton: CRC Press

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features : Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL. Preface Maria Freire What is a Biomarker and their Role in Drug Development? Definitions and conceptual framework of Biomarkers in Precision Medicine Claudio Carini, Mark D Fidock, Alain J van Gool In search of predictive biomarkers in cancer immunotherapy: Establishment of collaborative network for the validation process Giuseppe Masucci, Paola A Ascierto, Lisa Villabona Integrating personalized medicine in the healthcare: Payers and reimbursements Dominic Galante, Marylou Buyse Regulatory strategies to accelerate the implementation of biomarkers and companion diagnostics (CDX) F Owen Fields Biomarkers in Preclinical Sciences Lost in Translation – the challenges with the use of animal models in translational research Attila Seyhan,Claudio Carini Application of pharmacokinetic and pharmacodynamic modelling of biomarkers of efficacy in Translational research Neil Benson The DIAMONDS platform: Providing Decision Support for Toxicological Assessment based on Integration of Structural, Toxicological and Biomarker information Rob H Stierum, E Dinant Kroese, Jack TWE Vogels, Harrie Buist, Danyel GJ Jennen, Eugene P van Someren Predicting the (non)clinical toxicity of novel drug targets: an in silico perspective Jennifer Venhorst, Lars Verschuren, Annemette V Thougaard, Jorrit J Hornberg, Tanja Rouhani Rankouhi Unwanted Immunogenicity Responses to Biotherapeuitcs Shobha Purushothama, Boris Gorovits Biomarker use for advanced screening of drug-induced kidney injury Martijn J Wilmer, Frans GM Russel Soluble biomarkers for Cardiotoxicity Amy Pointon and Nick Edmunds Biomarkers in Translational Medicine Lost in Translation- Bridging the Pre-Clinical and Clinical Worlds Concepts, Examples, and Successes and Failure in Translational Medicine Attila Seyhan and Claudio Carini Necessary Characterization of Biomarkers to be "Fit for Purpose" Suso Platero　 Crucial role of high quality biosamples in biomarker development Cornelia Stumptner, Karine Sargsyan, Penelope Kungl, Kurt Zatloukal Informatics solution for biomarker discovery and personalized medicine in clinical care Jan Willem Boiten, Rita Azevedo, Marinel Cavelaars, André Dekker, Remond JA Fijneman, Arnoud van der Maas, Morris Swertz, Jeroen AN Beliën, Gerrit A Meijer Systems Biology Approaches to Identify New Biomarkers Lars Kuepfer, Andreas Schuppert The need for global collaboration in translational medicine Florence Bietrix, Antoni L Andreu, Giovanni Migliaccio, Anton E Ussi Biomarker-informed Clinical Trials Overview of biomarker discovery and statistical considerations Overview of classical design in biomarker informed clinical trials Bo Huang, Jing Wang, Robert A. Beckman, Sandeep Menon and Weidong Zhang Novel biomarker guided clinical trials design: A practical view Bo Huang, Jing Wang, Robert A. Beckman, Sandeep Menon and Weidong Zhang Outsourcing Biomarker Clinical Trials: Advantages and Disadvantages Robert Holt Case studies for biomarker based clinical trials Bo Huang, Jing Wang, Robert A. Beckman, Sandeep Menon and Weidong Zhang Informational designs and potential applications to Rare Disease Robert Beckman, Cong Chen The road ahead: Identification of the hurdles and solutions to the implementation of Precision Medicine in healthcare Paving a new era in patient centric care through innovations in Precision Medicine Mark Fidock, Glen Hughes, Alain J van Gool, Claudio Carini Integrating Molecular Testing into Early Stage Clinical Applications JonathanIWilde Ectopic gene deregulations and chromosome conformations: integrating novel molecular testing into clinical applications, from leukemias to gliomas" Francis Hector Grand, Matthew Salter, Ewan Hunter, Alexandre Akoulitchev Challenges and Opportunities of Next Generation Sequencing Companion Diagnostics Benoit Destenaves Implementing companion diagnostics Martina Kaufmann Publishing biomedical research findings - what are the odds? Andreas Scherer Computational Biology: Modeling from Molecule to Disease and Personalized Medicine Nina Kusch, Lisa Turnhoff, Andreas Schuppert Expectations for Quality Control: Challenges with multi-plex assays John L Allinson Lessons from the past and pioneers of the future Development of Mariviroc and the Companion Diagnostic HIV Tropism Assay Elna van der Ryst, James Demarest, Jayvant Heera, Mike Westby,Charles Knisch Case studies: Infertility and Anti-Müllerian Hormone Martin Hund, Joan-Carles Arce Factor Xa: Case Study Boris Gorovits Delivering Companion Diagnostics for Complex Biomarkers: The BRCA Companion Diagnostic Story for LYNPARZA TM (Olaparib) Maria C M Orr and Simon P Dearden Delivering the personalized medicine promise: best practice recommendations for designing biomarker development processes Karen KY Lam, Mary Zacour, Ji-Young V Kim, Zsuzsanna Hollander, Rhonda Wideman, Raymond T Ng, Scott J Tebbutt, Bruce M McManus Development, Launch and Adoption of a Pharmacodiagnostic: Planning Versus Reacting for Pharmaceutical Companies Mike Montalto, George Green Biomarker Consortia to drive BM discovery and clinical applications in the UK – lessons learned from RA-MAP John Isaacs, Sarah Brockbank, Ayako Pedersen Andrew Cope Measuring the Success of US biomarker Consortia Menetski Joseph The value of public-private partnerships in the Netherlands Hanna L Groen, Nico LU van Meeteren Paving a new era of personalized medicine: Emerging technologies A new era of personalized medicine: emerging technologies - functional proteomics, companion diagnostics and precision cancer medicine Michela Perani, Peter Parker The impact of epigenetics on the future of personalized medicine Jane Mellor Incorporating predictive imaging biomarkers in clinical trials for personalised healthcare John C Waterton Innovation in Metabonomics to improve personalized healthcare Nelma Pértega-Gomez and Massimo Loda Ultra-sensitive immunoassays to detect low abundant protein biomarkers Paul Wheeler Glycomics as an innovative approach for personalized medicine Stefanie Holst, Nurulamin Abu Bakar, Monique van Scherpenzeel, Manfred Wuhrer, Dirk J Lefeber miRNA as novel biomarkers of health and disease Laura García Bermejo Targeted proteomics for absolute quantification of protein biomarkers in serum and tissues Coşkun Güzel, Christoph Stingl, Frank Klont, Roel Tans, Esther Willems, Rainer Bischoff, Alain J van Gool, Theo M Luider, the Biomarker Development Center Consortium Integrated omics for tissue-based mapping of the human proteome Cecilia Lindskog Proteogenomics and multi-omics data integration for personalized medicine Peter Horvatovich, Corry-Anke Brandsma, Frank Suits, Rainer Bischoff, Victor Guryev Sequencing Approaches for Personalized Cancer Therapy Selection in Pathology Wendy de Leng, Manon Huibers, John Hinrichs, Edwin Cuppen, Stefan Willems Mass spectrometry imaging: enabling comprehensive spatial analysis of molecular biomarkers in tissue for personalized medicine Tiffany Porta, Steven WM Olde Damink, Ron MA Heeren Insights for personalized medicine from the gut microbiome: Lesson learned from celiac disease Gloria Serena, Anna Sapone, Alessio Fasano The next frontiers of therapeutic target areas: Autoimmunity, inflammation, respiratory, metabolic, cardiovascular and neurological diseases Precision Mucosal Sampling and Biomarkers in Allergic Rhinitis and Asthma Ashillesh Jha, Ryan S Thwaites, Nehmat Singh, Trevor Hansel Stratified medicine in autoimmune diseases John A Reynolds, Ian Bruce Biomarkers of Systemic Lupus Erythematosus Hiroshi Kato, Andras Perl Advances in cardiovascular Diagnostics – Use of cardiac biomarkers in clinical research and care of the patient Mark Effron and Zahoor Khan Biomarkers for psychiatric disease: an overview Roy Perlis Progressing towards precision psychiatry: current challenges in applying biomarkers in psychiatry Victor L Kallen, Brisa S Fernandes Identification of Biomarkers for the diagnosis, prediction and progression of Alzheimer’s Disease Bennett P Greenwood, Vladimir Tolstikov, Paula P Narain, Jeremy Chaufty, Viatcheslav R Akmaev, Vivek Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R Narain, Mike Kiebish Biomarkers in Lung Can