Annual review of microbiology, 2015-10, Vol.69 (1), p.31-48
2015
Details
- Autor(en) / Beteiligte
- Titel
- The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut
- Ist Teil von
- Annual review of microbiology, 2015-10, Vol.69 (1), p.31-48
- Ort / Verlag
- United States: Annual Reviews
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A metabolically diverse microbial community occupies all available nutrient-niches in the lumen of the mammalian intestine, making it difficult for pathogens to establish themselves in this highly competitive environment. Salmonella serovars sidestep the competition by using their virulence factors to coerce the host into creating a novel nutrient-niche. Inflammation-derived nutrients available in this new niche support a bloom of Salmonella serovars, thereby ensuring transmission of the pathogen to the next susceptible host by the fecal-oral route. Here we review the anaerobic food chain that characterizes resident gut-associated microbial communities along with the winning metabolic strategy Salmonella serovars use to edge out competing microbes in the inflamed intestine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4227eISSN: 1545-3251DOI: 10.1146/annurev-micro-091014-104108Titel-ID: cdi_annualreviews_primary_10_1146_annurev_micro_091014_104108
- Format
- –
- Schlagworte
- anaerobic respiration, Anaerobiosis, Animals, diarrhea, Digestive system, gastroenteritis, gastrointestinal pathogens, gut-associated microbial communities, Humans, Intestines - microbiology, Mammals, Metabolism, Microbial Interactions, Microbiology, Pathogens, Salmonella, Salmonella Infections - microbiology, Salmonella Infections - pathology, Salmonella typhimurium - growth & development, Salmonella typhimurium - metabolism, Salmonella typhimurium - pathogenicity, Virulence Factors - metabolism