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Annual review of biochemistry, 2002-06, Vol.71 (1), p.221-246
Ort / Verlag
Palo Alto, CA 94303-0139: Annual Reviews
Erscheinungsjahr
2002
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Metallocluster-containing enzymes catalyze some of the most basic redox
transformations in the biosphere. The reactions catalyzed by these enzymes
typically involve small molecules such as N
2
, CO, and H
2
that are used to generate both chemical building blocks and energy for
metabolic purposes. During the past decade, structures have been established
for the iron-sulfur-based metalloclusters present in the molybdenum
nitrogenase, the iron-only hydrogenase, and the nickel-carbon monoxide
dehydrogenase, and for the copper-sulfide-based cluster in nitrous oxide
reductase. Although these clusters are built from interactions observed in
simpler metalloproteins, they contain novel features that may be relevant for
their catalytic function. The mechanisms of metallocluster-containing enzymes
are still poorly defined, and represent substantial and continuing challenges
to biochemists, biophysicists, and synthetic chemists. These proteins also
provide a window into the union of the biological and inorganic worlds that may
have been relevant to the early evolution of biochemical catalysis.